The Chief of Mission, assisted by members of the Embassy staff, conducts the official business of the Government of the United States of America in Botswana. This includes the negotiation of treaties and agreements, the exchange of information on problem of mutual interests to the two countries, and sending of a flow of information to the United States on various subjects to enable officials and citizens of the United States to understand the attitudes and interests of Botswana.

The Chief of Mission also endeavors to make United States policies better known and understood in Botswana. The Embassy of Botswana in Washington D.C., performs similar tasks on behalf of Botswana Government.